Understanding how a small protein affects stress responses and cell function
Deciphering the ubiquitin code in stress signaling and membrane trafficking
This study is looking at how a tiny protein called ubiquitin helps our cells respond to stress, which could be important for understanding diseases like cancer and neurodegeneration, and it involves testing in both yeast and human cells to see how changes to ubiquitin affect cell behavior.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11000760 on NIH RePORTER |
What this research studies
This research investigates the role of ubiquitin, a small protein, in regulating various cellular processes, particularly in response to stress. By examining how modifications to ubiquitin influence protein behavior and interactions, the study aims to uncover mechanisms that could impact conditions like cancer and neurodegeneration. The research employs genetic, biochemical, and proteomic techniques to explore how specific changes to ubiquitin can alter cellular responses in both yeast and human cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions related to cellular stress, such as certain cancers or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to cellular stress or those not affected by the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to cellular stress and dysfunction.
How similar studies have performed: Previous research has shown that understanding protein modifications like ubiquitin can lead to significant advancements in treating various diseases, indicating a promising avenue for this investigation.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Macgurn, Jason a — Vanderbilt University
- Study coordinator: Macgurn, Jason a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.