Understanding how a protozoan communicates to control a human disease
Elucidation of the first interspecies chemical signaling mechanisms in Capsaspora owczarzaki--the predator of a human pathogen and a model for the evolution of animal multicellularity
This study is looking at how a tiny creature called Capsaspora owczarzaki, which eats harmful schistosome worms that cause schistosomiasis, interacts with its snail host and finds its food, with the hope of using this knowledge to help control this disease and learn more about how complex life forms evolved.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10866378 on NIH RePORTER |
What this research studies
This research investigates the chemical signaling mechanisms of Capsaspora owczarzaki, a protozoan that preys on schistosome worms, which are responsible for schistosomiasis. By studying how this organism interacts with its snail host and senses its prey, the research aims to uncover the molecular processes that govern its behavior. This could provide insights into the evolution of multicellularity in animals and enhance the potential of Capsaspora as a biocontrol agent against a neglected tropical disease. The approach involves identifying the specific molecules involved in adhesion and chemotaxis, which are crucial for understanding both the protozoan's predatory behavior and its relevance to human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in regions where schistosomiasis is prevalent, particularly those at risk of infection.
Not a fit: Patients who do not live in endemic areas for schistosomiasis or who are not at risk for this disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for controlling schistosomiasis, improving health outcomes for affected populations.
How similar studies have performed: While the specific chemical signaling mechanisms of Capsaspora are largely untested, similar approaches in studying other protozoans and their interactions with hosts have shown promise in understanding disease control.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Gerdt, Joseph P. — Trustees of Indiana University
- Study coordinator: Gerdt, Joseph P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.