Understanding how a protein related to Alzheimer's disease functions
Mechanisms of APP ectodomain function
['FUNDING_OTHER'] · OKLAHOMA MEDICAL RESEARCH FOUNDATION · NIH-11120599
This study is looking at a protein related to Alzheimer's disease to understand how it works in the brain and affects thinking, with the hope that this knowledge could help develop new treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA MEDICAL RESEARCH FOUNDATION (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-11120599 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the extracellular domain of the Amyloid Precursor Protein (APP), which is crucial in the development of Alzheimer's disease. The study aims to uncover how this protein interacts with other cellular components and its effects on cognitive functions. By exploring the mechanisms of ectodomain shedding, the research seeks to clarify how APP contributes to cellular signaling and potentially influences Alzheimer's pathology. Patients may benefit from insights gained that could lead to new therapeutic strategies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of APP in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- OKLAHOMA MEDICAL RESEARCH FOUNDATION — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RICE, HEATHER C. — OKLAHOMA MEDICAL RESEARCH FOUNDATION
- Study coordinator: RICE, HEATHER C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease