Understanding how a protein related to Alzheimer's disease functions
Mechanisms of APP ectodomain function
['FUNDING_OTHER'] · OKLAHOMA MEDICAL RESEARCH FOUNDATION · NIH-10862658
This study is looking at how a protein related to Alzheimer's disease affects brain cell communication and memory, with the hope of finding new ways to understand and treat the condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA MEDICAL RESEARCH FOUNDATION (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-10862658 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Amyloid Precursor Protein (APP) and its extracellular domain in cellular processes, particularly in relation to Alzheimer's disease. The study aims to uncover how APP shedding affects cellular signaling and cognitive functions, which could lead to new insights into Alzheimer's pathology. By exploring the interactions of soluble APP fragments with specific receptors, the research seeks to fill knowledge gaps regarding APP's physiological roles. Patients may benefit from a better understanding of Alzheimer's mechanisms, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into Alzheimer's disease mechanisms and lead to innovative treatment options.
How similar studies have performed: Previous research has shown promising results in understanding the roles of similar proteins in neurodegenerative diseases, suggesting potential for success in this area.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- OKLAHOMA MEDICAL RESEARCH FOUNDATION — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RICE, HEATHER C. — OKLAHOMA MEDICAL RESEARCH FOUNDATION
- Study coordinator: RICE, HEATHER C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease