Understanding how a protein regulates iron levels in the body
Regulation of hepatic hepcidin expression by transferrin receptor-2
This study is looking at how a protein called transferrin receptor-2 helps control iron levels in people with hereditary hemochromatosis, and it hopes to find new ways to improve treatment for issues caused by too much iron in the body, like liver problems and diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10901982 on NIH RePORTER |
What this research studies
This research investigates the role of transferrin receptor-2 (TfR2) in managing iron levels in the body, particularly in patients with hereditary hemochromatosis (HH). By using advanced techniques such as adeno-associated viral vectors and protein interaction assays, the study aims to uncover how mutations in TfR2 and related proteins disrupt iron homeostasis. The findings could lead to better understanding and potential treatments for conditions caused by iron overload, such as liver disease and diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with hereditary hemochromatosis or those with related iron overload conditions.
Not a fit: Patients without hereditary hemochromatosis or those not experiencing iron overload may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from iron overload disorders.
How similar studies have performed: Previous research has shown promising results in understanding iron regulation mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Enns, Caroline — Oregon Health & Science University
- Study coordinator: Enns, Caroline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.