Understanding how a protein regulates immune responses in the lungs during parasitic infections
Official title: Cul5 regulates lung ILC2 cells during helminth infection
Funded at Children's Hosp of Philadelphia · NIH-11046214 · Data updated 2026-11-12
This study is looking at how a protein called Cul5 helps control certain immune cells in the lungs during infections from parasitic worms, which can cause health problems and allergies, with the goal of finding better treatments for both these infections and allergic reactions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | November 14, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $659,341 |
| NIH project number | 1R01AI181999-01A1 |
| Project ID | NIH-11046214 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from helminth infections or those with allergic diseases linked to immune responses.
✕Less likely to help
Patients without helminth infections or allergic conditions may not benefit from this research.
What this research studies
This research investigates the role of a protein called Cul5 in regulating immune cells in the lungs during infections caused by parasitic worms. These infections can lead to serious health issues, including tissue damage and allergic reactions. By studying a specific type of immune cell known as ILC2 cells, the research aims to uncover how these cells respond to the presence of helminths and how they can sometimes mistakenly target harmless substances, leading to allergies. The findings could lead to new treatments for both helminth infections and allergic diseases.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic strategies for treating parasitic infections and allergic diseases.
How similar studies have gone: Previous research has shown promising results in understanding immune responses to parasitic infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Oliver, Paula Maria — Children's Hosp of Philadelphia
- Study coordinator: Oliver, Paula Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.