Understanding how a protein regulates ceramide production in cells
Regulation of Ceramide Synthase by Protein-Protein Interaction
This study is looking at how a specific protein interacts with enzymes that help produce important molecules called ceramides, which play a role in how our cells communicate and function, and it could help us understand more about certain diseases like cancer and Charcot-Marie-Tooth disease.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10799026 on NIH RePORTER |
What this research studies
This research investigates the regulation of ceramide synthase enzymes, which are crucial for producing ceramides, important molecules in cell signaling and metabolism. The study focuses on the interaction between ceramide synthase and a small heat shock protein called Hsp27, exploring how this interaction affects ceramide levels and cellular responses. By using advanced proteomics techniques, the researchers aim to uncover the biochemical and biological significance of this regulation, which could lead to new insights into various diseases, including certain cancers and Charcot-Marie-Tooth disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals affected by Charcot-Marie-Tooth disease or certain types of cancer.
Not a fit: Patients with conditions unrelated to ceramide metabolism or those not affected by the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to ceramide dysregulation.
How similar studies have performed: Previous research has shown promising results in understanding protein interactions and their implications in cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Senkal, Can Emre — Virginia Commonwealth University
- Study coordinator: Senkal, Can Emre
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.