Understanding how a protein regulates calcium signaling and lipid metabolism in Alzheimer's disease
Official title: Regulation of intracellular calcium signaling and phosphoinositide metabolism by IRBIT
Funded at Bates College · NIH-10702168 · Data updated 2026-11-12
This study is looking at how a protein called IRBIT influences important processes related to calcium and fat in cells, which could help us understand Alzheimer's disease better and find new ways to treat it.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bates College NIH-funded |
| Lab location | 1 site (Lewiston, United States) |
| Project start | September 7, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $415,443 |
| NIH project number | 1R15GM150377-01 |
| Project ID | NIH-10702168 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by Alzheimer's disease or related neurological conditions.
✕Less likely to help
Patients with conditions unrelated to Alzheimer's disease or those who do not have neurological disorders may not benefit from this research.
What this research studies
This research investigates the role of a protein called IRBIT in regulating calcium signaling and lipid metabolism, which are crucial processes in Alzheimer's disease and related conditions. By using human embryonic kidney cells, the researchers will analyze how IRBIT affects these signaling pathways through various techniques, including lipid mass spectrometry and live-cell imaging. The goal is to uncover the molecular mechanisms that contribute to Alzheimer's disease, potentially leading to new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for Alzheimer's disease and related neurological disorders.
How similar studies have gone: While the specific approach of studying IRBIT is novel, similar research has shown promise in understanding calcium signaling and lipid metabolism in neurological diseases.
Where this research is happening
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Bates College
Lewiston, United States Active
Researchers
- Principal investigator: Kruse, Martin — Bates College
- Study coordinator: Kruse, Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.