Understanding how a protein regulates brain signaling related to learning and memory
Regulation of NMDAR-Mediated Synaptic Signaling
This study is looking at how a protein called NRAP-1 helps control important brain receptors that affect learning and memory, using tiny worms to learn more about how this works and what it might mean for brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10990541 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, NRAP-1, in regulating NMDA receptors, which are crucial for synaptic signaling in the brain. By using a model organism called C. elegans, the researchers aim to understand how NRAP-1 affects the function of these receptors and their involvement in learning and memory processes. The study employs advanced techniques, including genetic screening and structural analysis, to explore the mechanisms behind NMDA receptor regulation and its implications for neurological disorders. The findings could provide insights into how synaptic strength is controlled in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological or psychiatric disorders that may involve NMDA receptor dysfunction.
Not a fit: Patients with conditions unrelated to NMDA receptor function or those not experiencing neurological or psychiatric symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurological and psychiatric disorders linked to NMDA receptor dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding NMDA receptor regulation, indicating that this approach has potential for significant advancements in the field.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Maricq, Andres Villu — University of Utah
- Study coordinator: Maricq, Andres Villu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.