Understanding how a protein regulates actin dynamics in cells
Official title: Actin regulation by cyclase-associated protein
Funded at Emory University · NIH-10999420 · Data updated 2026-11-12
This study is looking at how a protein called CAP helps control the building and breaking down of tiny structures in our cells that are important for movement and division, which could lead to better understanding and treatments for conditions related to how cells move and grow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | December 11, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $281,700 |
| NIH project number | 5R01GM144563-02 |
| Project ID | NIH-10999420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions related to abnormal cell motility or cancer.
✕Less likely to help
Patients with conditions unrelated to actin dynamics or cellular movement may not receive any benefit from this research.
What this research studies
This research investigates the role of cyclase-associated protein (CAP) in controlling the dynamics of actin filaments, which are crucial for various cellular processes such as movement and division. By studying how CAP interacts with other proteins like actin-depolymerizing factor (ADF) and cofilin, the research aims to uncover the mechanisms that enhance the disassembly of actin filaments. The approach involves advanced techniques like atomic force microscopy to visualize these interactions at a molecular level. Patients may benefit from insights gained into cellular behaviors that could impact conditions related to cell motility and division.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases involving abnormal cell movement or division.
How similar studies have gone: Other research has shown success in understanding actin dynamics and its regulation, making this approach promising and building on established knowledge.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Ono, Shoichiro — Emory University
- Study coordinator: Ono, Shoichiro
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.