Understanding how a protein protects the brain after a specific type of stroke.
Official title: Novel neurovascular protective mechanisms of PEDF after subarachnoid hemorrhage
Funded at Loma Linda University · NIH-10989904 · Data updated 2026-11-12
This study is looking at how a protein called PEDF might help protect the brain after a serious type of stroke called aneurysmal subarachnoid hemorrhage, with the hope that it could lead to better treatments for people who have experienced this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project start | December 1, 2021 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $364,500 |
| NIH project number | 5R01NS117179-04 |
| Project ID | NIH-10989904 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an aneurysmal subarachnoid hemorrhage.
✕Less likely to help
Patients who have not experienced a subarachnoid hemorrhage or those with other types of strokes may not benefit from this research.
What this research studies
This research investigates the protective effects of a protein called pigment-epithelium derived factor (PEDF) following aneurysmal subarachnoid hemorrhage (SAH), a severe type of stroke. The study focuses on how PEDF can reduce brain cell death, prevent damage to the blood-brain barrier, and mitigate inflammation that occurs after SAH. By using animal models, researchers aim to uncover the mechanisms through which PEDF operates to protect brain cells and improve outcomes for patients. The findings could lead to new therapeutic strategies for individuals affected by this condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and reduce long-term disabilities for patients who suffer from aneurysmal subarachnoid hemorrhage.
How similar studies have gone: While the protective effects of PEDF have been studied in other contexts, this specific investigation into its role after subarachnoid hemorrhage is novel and has not been extensively tested.
Where this research is happening
-
Loma Linda University
Loma Linda, United States Active
Researchers
- Principal investigator: Zhang, John H — Loma Linda University
- Study coordinator: Zhang, John H
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A potential treatment with adropin is being studied to protect brain cells after a subarachnoid hemorrhage and reduce stroke-like damage.
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A new manganese porphyrin-based drug is being explored as a possible treatment to reduce brain injury after a subarachnoid hemorrhage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.