Understanding how a protein modification affects diseases like cancer and arthritis
Chemical probes to decipher PAD biology
This research explores how a natural change in proteins, called citrullination, contributes to diseases such as cancer and rheumatoid arthritis, aiming to find new ways to help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11121780 on NIH RePORTER |
What this research studies
Our bodies naturally modify proteins through a process called citrullination, but too much of this change is linked to inflammatory diseases and cancer. This project aims to understand exactly how these protein changes affect human cells and contribute to illness. We are developing special chemical tools to identify which proteins are changed, how these changes impact their function, and if we can create new medicines to control this process. By answering these questions, we hope to gain a complete picture of how these protein changes influence human health.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical applications may benefit patients with inflammatory diseases or certain cancers.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new medicines that target specific protein changes, potentially offering new treatment options for conditions like rheumatoid arthritis, ulcerative colitis, nerve damage, and various cancers.
How similar studies have performed: Previous studies in animal models have shown that blocking protein citrullination can reduce disease severity, suggesting a promising path for this approach.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Thompson, Paul R — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Thompson, Paul R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.