Understanding how a protein linked to Parkinson's disease spreads in the brain
Official title: Activity-dependent release of human alpha-synuclein
Funded at Ohio University Athens · NIH-10575119 · Data updated 2026-11-12
This study is looking at how a protein linked to Parkinson's disease spreads in the brain, especially when the brain is under stress from things like injuries or lack of sleep, to find new ways to help slow down the disease for people living with it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio University Athens NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $403,010 |
| NIH project number | 1R21NS130256-01 |
| Project ID | NIH-10575119 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Parkinson's disease, particularly those with a history of traumatic brain injury or sleep deprivation.
✕Less likely to help
Patients with neurodegenerative diseases unrelated to alpha-synuclein or those without any risk factors for Parkinson's disease may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the release and spread of alpha-synuclein, a protein associated with Parkinson's disease. By examining how this protein behaves under different conditions, such as increased neuronal activity due to factors like traumatic brain injury or sleep deprivation, the study aims to uncover the genetic and molecular factors that influence its release. The researchers will use genetic models to better understand how mutations in alpha-synuclein affect its behavior and interactions in the nervous system. This knowledge could lead to new therapeutic targets for slowing or halting the progression of Parkinson's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or stop the progression of Parkinson's disease.
How similar studies have gone: Other research has shown promising results in understanding protein propagation in neurodegenerative diseases, making this approach both relevant and potentially impactful.
Where this research is happening
-
Ohio University Athens
Athens, United States Active
Researchers
- Principal investigator: Lee, Daewoo — Ohio University Athens
- Study coordinator: Lee, Daewoo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.