Understanding how a protein linked to Parkinson's disease interacts with brain cells
Structural basis and physiological consequences of alpha-Synuclein binding to neurexin 1beta
This study is looking at how a protein linked to Parkinson's disease interacts with another brain protein, hoping to understand how changes in this first protein might affect its behavior and contribute to the disease, which could help find new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10871686 on NIH RePORTER |
What this research studies
This research investigates the interactions between alpha-Synuclein, a protein associated with Parkinson's disease, and neurexin 1β, a glycoprotein in the brain. The study aims to uncover how modifications to alpha-Synuclein affect its binding to neurexin 1β and the subsequent internalization of the protein into cells. By using advanced techniques to analyze these interactions, the research seeks to clarify the mechanisms behind the spread of toxic forms of alpha-Synuclein in the brain, which may contribute to the progression of neurodegenerative disorders. Patients may benefit from insights gained that could lead to new therapeutic strategies for Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or those at risk of developing neurodegenerative disorders.
Not a fit: Patients with non-neurological conditions or those not affected by neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow or prevent the progression of Parkinson's disease.
How similar studies have performed: Other research has shown promising results in understanding protein interactions in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Rhoades, Elizabeth — University of Pennsylvania
- Study coordinator: Rhoades, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.