Understanding how a protein interacts with the HIV virus capsid
Official title: Characterization of full-lengh CPSF6 and its interaction with HIV capsid
Funded at Yale University · NIH-10839022 · Data updated 2026-11-12
This study is looking at how a protein in our cells interacts with the HIV virus to help it infect us, and by understanding this process better, we hope to find new ways to treat HIV.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $33,950 |
| NIH project number | 1F31AI181652-01 |
| Project ID | NIH-10839022 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
✕Less likely to help
Patients who are not infected with HIV or those who do not have a risk of HIV exposure may not benefit from this research.
What this research studies
This research investigates the interaction between a cellular protein called CPSF6 and the HIV capsid, which is crucial for the virus's ability to infect cells. By using advanced techniques to observe how CPSF6 binds to the HIV capsid, the research aims to uncover the mechanisms that allow the virus to enter the nucleus of host cells. The study is divided into three main aims, focusing on the biophysical properties of this interaction and its implications for HIV infection. Patients may benefit from insights gained that could lead to new therapeutic strategies against HIV.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent HIV from effectively infecting cells.
How similar studies have gone: Previous research has shown promising results in understanding viral interactions with host proteins, suggesting potential for breakthroughs in HIV treatment.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Freniere, Christian Joseph — Yale University
- Study coordinator: Freniere, Christian Joseph
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Community Health Worker–Led Hypertension Prevention and Control in Nepal
A community health worker–driven approach in Nepal aims to prevent and control high blood pressure among adults by bringing education and care directly to communities and homes.
-
Community health worker-led hypertension prevention and control in Nepal
A community health worker–led program in Nepal aims to help adults prevent and better control high blood pressure through home visits, education, and ongoing support.
-
Adapting a mobile health tool to boost HIV outcomes for older adults with HIV in Ukraine
A mobile health platform called PositiveLinks would be adapted for older adults with HIV in Ukraine to help them stay engaged in care and improve treatment success.
-
Behavioral and neural links between spoken language sounds and written words in young children
This grant studies how young children learn from listening and reading to improve literacy, by looking at how sound patterns transfer to written language.
-
Understanding how autoimmunity causes myasthenia gravis
This project looks at why the immune system attacks the nerve-muscle connection in myasthenia gravis and how different patient groups are affected.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.