Understanding how a protein interacts with the HIV virus capsid
Characterization of full-lengh CPSF6 and its interaction with HIV capsid
This study is looking at how a protein in our cells interacts with the HIV virus to help it infect us, and by understanding this process better, we hope to find new ways to treat HIV.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10839022 on NIH RePORTER |
What this research studies
This research investigates the interaction between a cellular protein called CPSF6 and the HIV capsid, which is crucial for the virus's ability to infect cells. By using advanced techniques to observe how CPSF6 binds to the HIV capsid, the research aims to uncover the mechanisms that allow the virus to enter the nucleus of host cells. The study is divided into three main aims, focusing on the biophysical properties of this interaction and its implications for HIV infection. Patients may benefit from insights gained that could lead to new therapeutic strategies against HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
Not a fit: Patients who are not infected with HIV or those who do not have a risk of HIV exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent HIV from effectively infecting cells.
How similar studies have performed: Previous research has shown promising results in understanding viral interactions with host proteins, suggesting potential for breakthroughs in HIV treatment.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Freniere, Christian Joseph — Yale University
- Study coordinator: Freniere, Christian Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.