Understanding how a protein interacts with insulin and affects obesity-related diseases
Elucidating Vascular Neuropilin 1 (NRP1) Functions in Response to Novel Interactions with Insulin Substrates
['FUNDING_R01'] · GEORGIA STATE UNIVERSITY · NIH-11010743
This study is looking at how a protein called Neuropilin 1 affects how our bodies handle insulin, especially for people dealing with obesity and related health problems like diabetes and heart disease, to help find better ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGIA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11010743 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called Neuropilin 1 (NRP1) in how the body responds to insulin, particularly in the context of obesity and related health issues. The study aims to uncover the mechanisms by which NRP1 influences metabolic processes and blood vessel formation, which are critical in conditions like diabetes and cardiovascular diseases. By examining the interactions between NRP1 and insulin substrates, the research seeks to provide insights into how obesity contributes to these diseases and identify potential therapeutic targets. Patients may benefit from a better understanding of how obesity affects their health and new strategies for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or related metabolic disorders, particularly those experiencing insulin resistance.
Not a fit: Patients who are not affected by obesity or metabolic syndromes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and reduce the risk of obesity-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of metabolic regulators in obesity, suggesting that this approach could yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- GEORGIA STATE UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DING, YE — GEORGIA STATE UNIVERSITY
- Study coordinator: DING, YE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus