Understanding how a protein interacts with arsenic to cause DNA damage
The Role of Aquaporin 3 in Arsenic-Induced DNA Damage and Mutagenesis
This study is looking at how a protein called Aquaporin 3 (AQP3) might help explain how small amounts of arsenic can harm our DNA and affect our health, with the goal of finding ways to prevent and treat illnesses related to arsenic exposure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-11248214 on NIH RePORTER |
What this research studies
This research investigates the role of Aquaporin 3 (AQP3) in the way low doses of arsenic can lead to DNA damage and potential health risks. The study aims to uncover the mechanisms by which AQP3 interacts with arsenic, mapping the specific areas of DNA damage it causes in human cells. By identifying the mutation signatures associated with this interaction, the research seeks to provide insights that could help in the prevention and treatment of diseases linked to arsenic exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to arsenic, particularly those living in areas with contaminated drinking water.
Not a fit: Patients who have not been exposed to arsenic or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the identification of early biomarkers for predicting long-term health impacts of arsenic exposure.
How similar studies have performed: While the specific interaction of AQP3 with low-dose arsenic is novel, previous research has shown that understanding DNA damage mechanisms can lead to significant advancements in disease prevention and treatment.
Where this research is happening
College Station, United States
- Texas A&m University Health Science Ctr — College Station, United States (Active)
Researchers
- Principal investigator: Xia, Jun — Texas A&m University Health Science Ctr
- Study coordinator: Xia, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.