Understanding how a protein influences immune responses in mucosal tissues
Perforin 2 controls unconventional cytokine release from mucosal APC
This study is looking at how a protein called Perforin 2 helps certain immune cells in your body release important signals that can affect inflammation, which is especially relevant for people with airway diseases, and it hopes to find new ways to improve treatments for these conditions.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11094098 on NIH RePORTER |
What this research studies
This research investigates the role of Perforin 2 in the release of cytokines from antigen-presenting cells (APCs) in mucosal tissues, which are crucial for regulating immune responses. The study focuses on how these cells deliver cytokines like IL-33 to T cells, impacting inflammation levels. By examining both human and mouse models, the research aims to clarify the mechanisms behind cytokine release and its implications for airway diseases. Patients may benefit from insights that could lead to new treatments for conditions related to immune responses in the respiratory system.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with airway diseases or conditions related to immune system dysfunction.
Not a fit: Patients with non-respiratory related immune conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing airway diseases by targeting immune responses.
How similar studies have performed: Other research has shown promising results in understanding immune responses through similar mechanisms, indicating potential for success in this area.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Herbert, De'broski R — Tulane University of Louisiana
- Study coordinator: Herbert, De'broski R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.