Understanding how a protein helps tuberculosis evade the immune system
Role of RNA-binding protein in immune evasion of Mtb in macrophages
This study is looking at how a specific protein helps the tuberculosis bacteria hide from our immune system, with the goal of finding new ways to help our bodies fight off this infection, especially the tougher, drug-resistant types.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10634764 on NIH RePORTER |
What this research studies
This research investigates the role of an RNA-binding protein called tristetraprolin (TTP) in how Mycobacterium tuberculosis (Mtb) avoids detection and destruction by the immune system, particularly within macrophages. By studying the mechanisms of immune evasion, the research aims to identify potential targets for new therapies that could enhance the body's ability to fight tuberculosis, especially drug-resistant strains. The approach includes examining the effects of TTP on the replication of Mtb and its interaction with immune responses in infected cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis, particularly those with drug-resistant forms of the disease.
Not a fit: Patients who do not have tuberculosis or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new host-directed therapies that improve treatment outcomes for tuberculosis patients.
How similar studies have performed: Previous research has shown promising results in targeting immune evasion mechanisms in other infectious diseases, suggesting potential for success in this novel approach to tuberculosis.
Where this research is happening
Saint Louis, United States
- Saint Louis University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Liu, Jianguo — Saint Louis University
- Study coordinator: Liu, Jianguo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.