Understanding how a protein helps stop bleeding
Structure and Function of the VWF Helical Tubule Required for Hemostasis
This study is looking at a protein called von Willebrand Factor that helps your blood clot, especially for people with von Willebrand Disease, to see how it works and how changes in its structure might affect its ability to stop bleeding, with the hope of finding better treatments for you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11012323 on NIH RePORTER |
What this research studies
This research investigates the structure and function of a specific protein called von Willebrand Factor (VWF), which is crucial for blood clotting. It focuses on how VWF forms long chains that help platelets stick together to stop bleeding, particularly in patients with von Willebrand Disease (VWD). The researchers will use advanced techniques to visualize the helical structures of VWF during its maturation process and examine how mutations affect its ability to function properly. By understanding these mechanisms, the research aims to improve treatment options for bleeding disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with von Willebrand Disease or those with a family history of bleeding disorders.
Not a fit: Patients with bleeding disorders caused by factors other than von Willebrand Factor mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better therapies for patients with bleeding disorders, particularly those with von Willebrand Disease.
How similar studies have performed: Previous research has shown promising results in understanding the structure of blood proteins, making this approach both relevant and potentially impactful.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Anderson, Jacob R — Harvard Medical School
- Study coordinator: Anderson, Jacob R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.