Understanding how a protein helps repair DNA damage caused by certain chemicals
Official title: Determining the structural basis of polyubiquitin signaling in response to DNA alkylation damage
Funded at Mount St. Mary's University · NIH-10796099 · Data updated 2026-11-12
This study is looking at how a protein called ASCC2 helps fix DNA damage caused by certain harmful substances, which could lead to better treatments for people dealing with conditions related to DNA damage.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mount St. Mary's University NIH-funded |
| Lab location | 1 site (Emmitsburg, United States) |
| Project start | September 15, 2020 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $443,997 |
| NIH project number | 2R15GM140410-02 |
| Project ID | NIH-10796099 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced DNA damage due to exposure to alkylating agents or have conditions related to impaired DNA repair mechanisms.
✕Less likely to help
Patients with conditions unrelated to DNA damage or those not exposed to alkylating agents may not benefit from this research.
What this research studies
This research investigates how the protein ASCC2 interacts with specific types of polyubiquitin chains that are crucial for repairing DNA damage caused by alkylating agents. By using advanced techniques like nuclear magnetic resonance (NMR) spectroscopy and integrative modeling, the researchers aim to uncover the precise molecular interactions that allow ASCC2 to recognize and bind these chains. The findings could enhance our understanding of cellular responses to DNA damage and potentially lead to improved therapeutic strategies. Patients may benefit from insights gained about DNA repair mechanisms that could inform treatment options for conditions related to DNA damage.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients affected by DNA damage-related conditions.
How similar studies have gone: While the specific approach of this research may be novel, similar studies have shown success in understanding protein interactions involved in DNA repair mechanisms.
Where this research is happening
-
Mount St. Mary's University
Emmitsburg, United States Active
Researchers
- Principal investigator: Lombardi, Patrick — Mount St. Mary's University
- Study coordinator: Lombardi, Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.