Understanding how a protein helps other proteins fold correctly
Official title: Determinants of the Hsp90-client interaction
Funded at University of Idaho · NIH-10670003 · Data updated 2026-11-12
This study is looking at a special protein called Hsp90 to see how it helps other proteins work properly, with the hope of creating new treatments for diseases like cancer and cystic fibrosis by improving how these proteins function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Idaho NIH-funded |
| Lab location | 1 site (Moscow, United States) |
| Project start | September 16, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $61,038 |
| NIH project number | 3R01GM127675-04S1 |
| Project ID | NIH-10670003 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cancers or cystic fibrosis who may benefit from targeted protein therapies.
✕Less likely to help
Patients with conditions unrelated to protein folding or those not diagnosed with cancer or cystic fibrosis may not receive benefits from this research.
What this research studies
This research investigates the role of the Hsp90 protein, which is crucial for the proper folding and functioning of many other proteins in the body. By examining how Hsp90 interacts with its client proteins, the researchers aim to develop targeted compounds that can selectively influence specific protein interactions. This could lead to new treatments for various diseases, including cancers and cystic fibrosis, by improving the way proteins function in these conditions. The study employs innovative techniques to manipulate Hsp90 and its associated proteins to gain insights into their mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve protein function in diseases like cancer and cystic fibrosis.
How similar studies have gone: Previous research has shown promise in targeting protein interactions for therapeutic purposes, suggesting potential success for this approach.
Where this research is happening
-
University of Idaho
Moscow, United States Active
Researchers
- Principal investigator: Johnson, Jill L — University of Idaho
- Study coordinator: Johnson, Jill L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.