Understanding how a protein helps HIV and COVID-19 viruses assemble
Official title: Determining the role of AnnexinA2 in HIV-1 and SARS-CoV-2 assembly
Funded at California State University Long Beach · NIH-10937390 · Data updated 2026-11-12
This study is looking at how a protein called AnnexinA2 helps the HIV and COVID-19 viruses to infect cells better, with the hope that understanding this process will lead to new treatments for these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Long Beach NIH-funded |
| Lab location | 1 site (Long Beach, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $180,599 |
| NIH project number | 1R16AI184450-01 |
| Project ID | NIH-10937390 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by HIV-1 or COVID-19, particularly those who may benefit from novel antiviral therapies.
✕Less likely to help
Patients who are not infected with HIV-1 or SARS-CoV-2 may not receive direct benefits from this research.
What this research studies
This research investigates the role of a protein called AnnexinA2 in the assembly of HIV-1 and SARS-CoV-2 viruses. By studying how these viruses use lipid rafts—specialized areas in cell membranes—to enhance their infection capabilities, the research aims to uncover the mechanisms that allow these viruses to thrive. The approach involves examining the interaction between AnnexinA2 and viral proteins, which could lead to new therapeutic strategies to combat these infections. Patients may benefit from insights gained that could inform the development of antiviral therapies targeting these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce the impact of HIV and COVID-19 infections.
How similar studies have gone: Previous research has shown that targeting viral assembly mechanisms can be effective, suggesting potential success for this approach.
Where this research is happening
-
California State University Long Beach
Long Beach, United States Active
Researchers
- Principal investigator: Ramirez, Peter William — California State University Long Beach
- Study coordinator: Ramirez, Peter William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.