Understanding how a protein from Chlamydia trachomatis affects infection processes
Dissecting the role of the Inclusion membrane protein IncE, a master multi-tasking scaffolding protein, in the pathogenesis of Chlamydia trachomatis infections
This study is looking at a protein made by the Chlamydia bacteria to see how it helps the bacteria infect and stay in human cells, which could lead to new ways to treat Chlamydia infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10870158 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, IncE, produced by the Chlamydia trachomatis bacterium, in how the bacteria establish and maintain their infection within human cells. The study focuses on how IncE interacts with host cell proteins that are crucial for cellular trafficking, potentially altering the way the bacteria manipulate the host's cellular environment. By examining these interactions, the research aims to uncover new insights into the mechanisms of Chlamydia infections, which could lead to innovative treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Chlamydia trachomatis infections or those at high risk of such infections.
Not a fit: Patients with other types of bacterial infections or those who do not have Chlamydia trachomatis infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapeutic approaches for treating Chlamydia trachomatis infections.
How similar studies have performed: Other research has shown success in understanding bacterial pathogenesis through similar molecular approaches, indicating potential for impactful findings in this area.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Engel, Joanne N. — University of California, San Francisco
- Study coordinator: Engel, Joanne N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.