Understanding how a protein from a virus involved in Kaposi's sarcoma works
Official title: Elucidating the molecular function of Kaposi's sarcoma-associated herpesvirus packaging accessory protein ORF68
Funded at Yale University · NIH-10997774 · Data updated 2026-11-12
This study is looking at a protein from the virus that causes Kaposi's sarcoma to understand how it works and how it helps the virus spread, with the hope of finding new ways to treat or prevent related diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $33,980 |
| NIH project number | 1F31AI181429-01A1 |
| Project ID | NIH-10997774 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by Kaposi's sarcoma or those at high risk for KSHV infection.
✕Less likely to help
Patients who do not have KSHV or Kaposi's sarcoma may not benefit from this research.
What this research studies
This research investigates the molecular function of a specific protein, ORF68, from the Kaposi's sarcoma-associated herpesvirus (KSHV). By exploring how this protein interacts with DNA and its role during the virus's infection process, the research aims to fill critical knowledge gaps that could lead to new therapies. The study will utilize various experimental approaches, including in vivo assessments, to understand the protein's behavior and its importance in viral packaging. Ultimately, this work seeks to develop strategies to limit the spread of KSHV and prevent associated diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively limit the spread of KSHV and reduce the incidence of Kaposi's sarcoma.
How similar studies have gone: While the specific approach of targeting the ORF68 protein is novel, similar research on other herpesviruses has shown promise in understanding viral mechanisms and developing therapeutic targets.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Gelles-Watnick, Sara — Yale University
- Study coordinator: Gelles-Watnick, Sara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.