Understanding how a protein from a virus involved in Kaposi's sarcoma works
Elucidating the molecular function of Kaposi's sarcoma-associated herpesvirus packaging accessory protein ORF68
['FUNDING_FELLOWSHIP'] · YALE UNIVERSITY · NIH-10997774
This study is looking at a protein from the virus that causes Kaposi's sarcoma to understand how it works and how it helps the virus spread, with the hope of finding new ways to treat or prevent related diseases.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10997774 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular function of a specific protein, ORF68, from the Kaposi's sarcoma-associated herpesvirus (KSHV). By exploring how this protein interacts with DNA and its role during the virus's infection process, the research aims to fill critical knowledge gaps that could lead to new therapies. The study will utilize various experimental approaches, including in vivo assessments, to understand the protein's behavior and its importance in viral packaging. Ultimately, this work seeks to develop strategies to limit the spread of KSHV and prevent associated diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by Kaposi's sarcoma or those at high risk for KSHV infection.
Not a fit: Patients who do not have KSHV or Kaposi's sarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively limit the spread of KSHV and reduce the incidence of Kaposi's sarcoma.
How similar studies have performed: While the specific approach of targeting the ORF68 protein is novel, similar research on other herpesviruses has shown promise in understanding viral mechanisms and developing therapeutic targets.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GELLES-WATNICK, SARA — YALE UNIVERSITY
- Study coordinator: GELLES-WATNICK, SARA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Cancer Cause