Understanding how a protein controls the production of histone proteins during cell division
Official title: The Mute button: Turning down the volume of histone expression
Funded at Univ of North Carolina Chapel Hill · NIH-10892066 · Data updated 2026-11-12
This study is looking at how a protein called Mute helps control the production of histones, which are important for keeping our DNA organized during cell division, and it could help us understand more about how cells work and how this might relate to different diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HD113267-02 |
| Project ID | NIH-10892066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions related to cell cycle dysregulation or genomic instability.
✕Less likely to help
Patients with stable, non-proliferative conditions may not receive any direct benefit from this research.
What this research studies
This research investigates the role of a protein called Mute in regulating the expression of histone genes during the cell division cycle. Histones are essential for packaging DNA, and their production must be carefully controlled to maintain genomic integrity. The study will explore how Mute acts as a negative regulator of histone gene expression, particularly during the S-phase of cell division, using advanced techniques like ATAC sequencing. By understanding these mechanisms, the research aims to shed light on the fundamental processes of cell biology that could have implications for various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cell cycle regulation and potential therapeutic targets for diseases related to DNA damage and cell proliferation.
How similar studies have gone: While the specific role of Mute in histone regulation is novel, similar studies have successfully identified key regulatory proteins in cell cycle control.
Where this research is happening
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Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Geisler, Mark Stephen — Univ of North Carolina Chapel Hill
- Study coordinator: Geisler, Mark Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.