Understanding how a protein complex unfolds and processes other proteins in cells
Mechanism of Substrate Unfolding by the AAA+ ATPase p97 and Binding Partners
This study is looking at a protein called p97 that helps keep our cells healthy by managing damaged proteins, and it aims to understand how problems with p97 can lead to diseases, which could help patients in the future.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10894618 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called p97, which is essential for maintaining protein balance in cells. It focuses on how p97 interacts with its binding partners to unfold and prepare damaged proteins for degradation. By studying the structure and function of p97 and its partners, the research aims to uncover the mechanisms behind protein processing and how mutations in p97 can lead to diseases. Patients may benefit from insights gained into the cellular processes that maintain protein health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations affecting protein processing or diseases related to proteostasis.
Not a fit: Patients with conditions unrelated to protein misfolding or degradation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases caused by protein misfolding and degradation.
How similar studies have performed: Previous research has shown promising results in understanding protein processing mechanisms, indicating that this approach has potential for success.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Mack, Deirdre — University of Utah
- Study coordinator: Mack, Deirdre
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.