Understanding how a protein complex regulates gene expression in cancer
Structural insights into the Argonaute-containing CDK8 complex
This study is looking at a protein complex called the Cdk8 kinase module, which helps control how genes work, especially in breast and colorectal cancer, to find out how it activates and interacts with other molecules, with the hope of discovering new ways to treat these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10922849 on NIH RePORTER |
What this research studies
This research investigates the Cdk8 kinase module, a protein complex that plays a crucial role in regulating gene expression, particularly in the context of cancers like breast and colorectal cancer. By using advanced techniques such as cryo-electron microscopy, the researchers aim to uncover the structural details and functional mechanisms of this complex. The study will explore how the Cdk8 module is activated and how it interacts with other molecules to influence gene transcription. This knowledge could lead to new insights into cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast or colorectal cancer, particularly those with mutations in the Cdk8 complex.
Not a fit: Patients with cancers unrelated to the Cdk8 complex or those without genetic mutations in this pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting gene regulation in cancer treatment.
How similar studies have performed: Previous research has shown promising results in understanding similar protein complexes and their roles in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Tsai, Kuang-Lei — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Tsai, Kuang-Lei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.