Understanding how a protein complex regulates gene expression during stress
Activities of yeast Ccr4-Not transcription factor complex
This study looks at a special protein complex in yeast that helps control how genes work, especially when the yeast is under stress, to better understand how cells manage their functions during tough times.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-10821459 on NIH RePORTER |
What this research studies
This research investigates the Ccr4-Not transcription factor complex in yeast, which plays a crucial role in regulating gene expression, particularly during stress responses. The study employs various methodologies, including genetics and molecular biology, to explore how this complex influences processes like mRNA decay and protein destruction. By identifying the targets of the complex and understanding its mechanisms, the research aims to shed light on how cells maintain balance in gene expression under challenging conditions.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions linked to gene expression dysregulation, such as certain cancers or genetic disorders.
Not a fit: Patients with acute conditions unrelated to gene expression or stress responses may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for diseases related to gene expression and stress responses.
How similar studies have performed: Other research has shown success in understanding gene regulation mechanisms, making this approach promising yet still exploring novel aspects of the Ccr4-Not complex.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Reese, Joseph C — Pennsylvania State University, the
- Study coordinator: Reese, Joseph C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.