Understanding how a protein complex regulates gene expression and responds to DNA damage
Official title: Identification and structural basis of a potential licensing factor of the Integrator cleavage module
Funded at University of Rochester · NIH-11023037 · Data updated 2026-11-12
This study is looking at how a special protein complex helps control gene activity and repairs DNA when cells are stressed, which could lead to new treatments for cancer and other related conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 5F31CA284555-02 |
| Project ID | NIH-11023037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic predispositions to cancer, particularly those with mutations in the BRCA1 gene.
✕Less likely to help
Patients with conditions unrelated to gene expression regulation or DNA damage repair may not benefit from this research.
What this research studies
This research investigates the Integrator complex, which plays a crucial role in regulating gene expression by controlling the transcription process. The study focuses on how this complex interacts with proteins involved in DNA damage repair, particularly in response to stressors like reactive oxygen species. By using advanced techniques such as cryo-electron microscopy, the researchers aim to uncover the structural details of these interactions, which could lead to a better understanding of cellular responses to damage. This knowledge may help identify new therapeutic targets for conditions related to gene regulation and cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to gene expression dysregulation, including certain cancers.
How similar studies have gone: Previous research has shown promising results in understanding the role of transcriptional regulators in cancer, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Jensen, Madeline K — University of Rochester
- Study coordinator: Jensen, Madeline K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.