Understanding how a protein complex regulates gene activity and its role in cancer
Molecular Basis of Gene Regulation by Polycomb Repressive Complex 2
This study is looking at a protein complex called PRC2 that helps keep our cells healthy and working properly, and it's trying to understand how problems with PRC2 might be linked to certain cancers and developmental disorders, which could lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10810682 on NIH RePORTER |
What this research studies
This research investigates the Polycomb Repressive Complex 2 (PRC2), which is crucial for maintaining cell identity and regulating gene expression. By examining how PRC2 functions at the molecular level, the research aims to uncover its role in various cancers and developmental disorders. The approach involves studying the complex interactions of PRC2 with other cellular factors and its impact on gene silencing through specific modifications of histones. Patients may benefit from insights into how disruptions in PRC2 contribute to cancer, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with cancers linked to PRC2 dysfunction.
Not a fit: Patients with cancers unrelated to PRC2 dysregulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers associated with PRC2 dysregulation.
How similar studies have performed: Other research has shown promising results in understanding the role of PRC2 in cancer, indicating that this approach has potential for significant findings.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Liu, Xin — Ut Southwestern Medical Center
- Study coordinator: Liu, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.