Understanding how a protein complex influences gene activity in cancer and developmental disorders
Role of BAP1/ASXL3 complex in transcriptional regulation and development
['FUNDING_OTHER'] · NORTHWESTERN UNIVERSITY · NIH-11109563
This project aims to understand how certain proteins control gene activity, which could help us find new ways to treat cancers and developmental disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11109563 on ClinicalTrials.gov |
What this research studies
Our bodies have complex systems that turn genes on and off, which is crucial for healthy development and preventing diseases like cancer. This project explores a specific group of proteins, called the BAP1/ASXL3 complex, that helps control these gene switches. When these proteins don't work correctly, it can lead to developmental problems, nerve disorders, and various cancers. By learning exactly how this complex regulates genes, we hope to uncover new ways to identify and treat these serious conditions.
Who could benefit from this research
Good fit: This foundational research is relevant for patients affected by certain cancers, developmental disorders, and neuronal conditions linked to gene regulation.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose and treat cancers and developmental disorders by targeting specific gene regulation pathways.
How similar studies have performed: Research into epigenetic factors has shown promise in understanding disease mechanisms, and this project builds upon previous findings in this area.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, LU — NORTHWESTERN UNIVERSITY
- Study coordinator: WANG, LU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Disease, Disorder