Understanding how a protein complex affects red blood cell production
Elucidating the Role of Integrator Complex in Erythropoiesis
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-11052510
This study is looking at how a special group of proteins helps make red blood cells, which are important for keeping your blood healthy and preventing anemia, so that we can find better ways to understand and treat this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11052510 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Integrator Complex in the production of red blood cells, a process crucial for maintaining healthy blood levels and preventing anemia. The study focuses on how this complex interacts with RNA polymerase II, a key enzyme in gene expression, to regulate the genes necessary for red blood cell maturation. By examining the mechanisms that control the transition of precursor cells into fully functional red blood cells, the research aims to uncover new insights into erythropoiesis. Patients may benefit from a better understanding of anemia and potential new treatments that target these cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are experiencing anemia or related blood disorders.
Not a fit: Patients with non-hematological conditions or those under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for anemia and other blood disorders by enhancing our understanding of red blood cell production.
How similar studies have performed: While the specific role of the Integrator Complex in erythropoiesis is not well-studied, similar research has shown promise in understanding gene regulation in blood cell development.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STEINER, LAURIE A. — UNIVERSITY OF ROCHESTER
- Study coordinator: STEINER, LAURIE A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.