Understanding how a protein complex affects red blood cell production
Official title: Elucidating the Role of Integrator Complex in Erythropoiesis
Funded at University of Rochester · NIH-11052510 · Data updated 2026-11-12
This study is looking at how a special group of proteins helps make red blood cells, which are important for keeping your blood healthy and preventing anemia, so that we can find better ways to understand and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $385,000 |
| NIH project number | 5R01HL173979-02 |
| Project ID | NIH-11052510 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are experiencing anemia or related blood disorders.
✕Less likely to help
Patients with non-hematological conditions or those under 21 years old may not receive any benefit from this research.
What this research studies
This research investigates the role of the Integrator Complex in the production of red blood cells, a process crucial for maintaining healthy blood levels and preventing anemia. The study focuses on how this complex interacts with RNA polymerase II, a key enzyme in gene expression, to regulate the genes necessary for red blood cell maturation. By examining the mechanisms that control the transition of precursor cells into fully functional red blood cells, the research aims to uncover new insights into erythropoiesis. Patients may benefit from a better understanding of anemia and potential new treatments that target these cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for anemia and other blood disorders by enhancing our understanding of red blood cell production.
How similar studies have gone: While the specific role of the Integrator Complex in erythropoiesis is not well-studied, similar research has shown promise in understanding gene regulation in blood cell development.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Steiner, Laurie a. — University of Rochester
- Study coordinator: Steiner, Laurie a.
Related research
Other NIH-funded projects on the same topics.
-
Rapid automated breast lump diagnosis without a radiologist or sonographer
A new AI-powered ultrasound tool helps determine if a palpable breast lump is likely benign or malignant, using a simplified technique that can be used by people with minimal ultrasound training.
-
ML-ROVER: Reducing Unneeded Lab Tests in Kids with AI
Aims to use machine learning to cut unnecessary blood tests in children in intensive care, helping avoid anemia and improve care quality.
-
Aggressive fever-reducing therapy to protect the brains of children with CNS malaria
A study planned for children with CNS malaria will test whether aggressive fever-reducing treatment can lower death and brain-related problems.
-
Aggressive fever-reducing therapy to protect brains in children with CNS malaria
A plan to test whether giving strong fever-reducing medications to children with central nervous system malaria can lower death and brain injury.
-
Aggressive fever-fighting treatment to protect the brain in kids with CNS malaria
A plan to test whether giving strong fever-reducing treatment alongside standard care can lower death and brain injury in children with CNS malaria.
-
Aggressive fever-reducing treatment to protect brains in kids with CNS malaria
A plan to test whether giving strong fever-reducing medicine alongside standard malaria treatment can lower deaths and brain injuries in children with CNS malaria.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.