Understanding how a protein complex affects insulin signaling
Mechanism and Function of the Supercomplex KARATE in Insulin Signaling
This study is looking at a protein called KARATE to see how it helps insulin work better in the body, which could lead to new ways to treat insulin resistance and type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11014444 on NIH RePORTER |
What this research studies
This research investigates the role of a protein complex called KARATE in insulin signaling, which is crucial for regulating blood sugar levels. By examining how this complex interacts with key proteins involved in glucose uptake and metabolism, the study aims to uncover mechanisms that could lead to better treatments for insulin resistance and type 2 diabetes. The researchers will use advanced biochemical techniques to analyze the assembly and function of KARATE in cells, focusing on its impact on glucose homeostasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with insulin resistance or type 2 diabetes who are seeking new treatment options.
Not a fit: Patients with type 1 diabetes or those not experiencing insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating insulin resistance and improving blood sugar control in patients with type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding insulin signaling pathways, but the specific role of the KARATE complex is a novel area of investigation.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Iijima, Miho — Johns Hopkins University
- Study coordinator: Iijima, Miho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.