Understanding how a protein complex affects immune response and lymphoma development
Role of chromatin remodeling complex BAF in immunity and lymphoma
['FUNDING_OTHER'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11137188
This study is looking at how a specific protein complex affects the immune system and its link to a type of lymphoma called diffuse large B cell lymphoma (DLBCL), with the hope of finding new ways to help patients understand their condition and improve treatment options.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11137188 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the BAF chromatin remodeling complex in regulating immune responses and its connection to lymphoma, particularly diffuse large B cell lymphoma (DLBCL). The researchers will explore how BAF influences the differentiation of B cells and their ability to respond to immune challenges. By using advanced genomic techniques, they aim to uncover the mechanisms by which BAF mutations contribute to cancer development, potentially leading to new therapeutic strategies. Patients may benefit from insights gained about their lymphoma and immune function.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with diffuse large B cell lymphoma or those with mutations in BAF complex genes.
Not a fit: Patients with other types of cancers or immune disorders not related to BAF mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with lymphoma and related immune disorders.
How similar studies have performed: Previous research has shown that targeting chromatin remodeling complexes can be effective in cancer treatment, suggesting a promising avenue for this investigation.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARISIC, DARKO — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: BARISIC, DARKO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.