Understanding how a protein complex affects gene regulation and cell signaling
Official title: Regulation of exon junction complex composition and assembly
Funded at University of Rochester · NIH-10992605 · Data updated 2026-11-12
This study is looking at how a protein called AKT affects a group of molecules that help control gene activity, which could give us new ideas for treating diabetes and some genetic disorders.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $125,000 |
| NIH project number | 5K99GM152790-02 |
| Project ID | NIH-10992605 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with type 1 or type 2 diabetes, as well as those affected by Fragile X syndrome.
✕Less likely to help
Patients with conditions unrelated to gene regulation or the specific pathways being studied may not benefit from this research.
What this research studies
This research investigates the exon junction complex (EJC), which plays a crucial role in gene expression by regulating mRNA decay. It focuses on how the AKT protein, a key player in cell signaling, influences the composition of the EJC and its impact on conditions like diabetes and certain genetic disorders. By exploring the mechanisms of EJC formation and its regulation by insulin, the research aims to uncover new insights into cellular processes that could lead to better understanding and treatment of related diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetes and genetic disorders by targeting the mechanisms of gene regulation.
How similar studies have gone: Previous research has shown promising results in understanding the role of cell signaling in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Abshire, Elizabeth Tenley — University of Rochester
- Study coordinator: Abshire, Elizabeth Tenley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.