Understanding how a protein complex affects blood vessel function
Official title: LRRC8 complex regulation of endothelial function
Funded at Washington University · NIH-11013399 · Data updated 2026-11-12
This study is looking at how a specific protein helps control blood vessel function and responds to different signals, which could lead to better treatments for conditions like diabetes and high blood pressure, ultimately helping patients improve their vascular health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $510,429 |
| NIH project number | 5R01HL168600-03 |
| Project ID | NIH-11013399 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with conditions such as Type 2 diabetes or hypertension who may experience vascular dysfunction.
✕Less likely to help
Patients without vascular issues or those not affected by diabetes or hypertension may not benefit from this research.
What this research studies
This research investigates the role of the LRRC8 protein complex in regulating blood vessel function, particularly how it responds to various chemical and mechanical signals. By studying how this complex influences important signaling pathways related to blood flow and pressure, the research aims to uncover mechanisms that could lead to better treatments for conditions like adult-onset diabetes and hypertension. The approach includes using animal models to observe changes in vascular function and signaling in response to different stimuli. Patients may benefit from insights gained about how to improve vascular health and manage related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving blood vessel function in patients with diabetes and hypertension.
How similar studies have gone: Previous research has shown promising results in understanding the role of endothelial signaling in vascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Sah, Rajan — Washington University
- Study coordinator: Sah, Rajan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.