Understanding how a protein complex affects blood cell development and leukemia
The role of the cohesin complex in hematopoietic transformation and leukemia maintenance
['FUNDING_R37'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10931725
This study is looking at how a protein called Stag2 affects the development of acute myeloid leukemia (AML) by exploring changes in blood cells and their genes, with the hope that finding a way to restore Stag2 could lead to new treatments for leukemia.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10931725 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the cohesin complex, specifically the Stag2 protein, in the development and maintenance of acute myeloid leukemia (AML). By examining how the loss of Stag2 affects the three-dimensional structure of chromatin and gene expression, researchers aim to identify critical changes that occur during blood cell differentiation and self-renewal. The study employs advanced techniques such as Hi-ChIP assays and RNA sequencing to analyze chromatin features in both mouse and human blood stem cells. The ultimate goal is to determine whether restoring Stag2 can reverse the effects of its loss, potentially leading to new therapeutic strategies for leukemia.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with acute myeloid leukemia or myelodysplastic syndromes.
Not a fit: Patients with other types of blood cancers or those without a diagnosis of leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for patients with acute myeloid leukemia by targeting the underlying genetic and epigenetic mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding the role of chromatin structure in leukemia, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VINY, AARON D — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: VINY, AARON D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.