Understanding how a protein can help control blood clotting
Official title: Structure and Biology of Tissue Factor Pathway Inhibitor-2
Funded at University of California Los Angeles · NIH-11175777 · Data updated 2026-11-12
This study is looking at a protein that helps control blood clotting, and it's trying to create new versions of this protein that can help prevent excessive bleeding during surgeries, making treatments safer for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 9, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $511,135 |
| NIH project number | 1R56HL169862-01A1 |
| Project ID | NIH-11175777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing major surgeries who are at risk of excessive bleeding.
✕Less likely to help
Patients with conditions unrelated to blood coagulation or those not undergoing surgical procedures may not benefit from this research.
What this research studies
This research investigates the structure and function of a protein called tissue factor pathway inhibitor-2 (TFPI-2), which plays a crucial role in regulating blood clotting. The researchers aim to identify specific parts of this protein that inhibit certain enzymes involved in clot formation and breakdown. By designing new variants of TFPI-2 that selectively target these enzymes, the study seeks to develop safer treatments that can reduce excessive bleeding during major surgeries without the side effects of existing treatments. Patients may benefit from these advancements in surgical care and blood management.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for managing bleeding during surgeries.
How similar studies have gone: Previous research has shown promise in developing targeted inhibitors for blood coagulation, indicating potential success for this novel approach.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Vadivel, Kanagasabai — University of California Los Angeles
- Study coordinator: Vadivel, Kanagasabai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.