Understanding how a protein called TULP3 helps our cells' tiny antennae function
TULP3 integrates essential ciliary functions
This research explores how a key protein called TULP3 helps tiny cell structures called cilia, which are important for sensing signals and preventing many health problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11109527 on NIH RePORTER |
What this research studies
Primary cilia are like tiny antennae on our cells that sense signals from their surroundings. When these cilia don't work correctly, it can lead to many health issues, including developmental disorders, immune problems, diabetes, obesity, Parkinson's disease, and cancer. This project focuses on a specific protein, TULP3, which is crucial for cilia to function properly, especially in how they receive and process signals. Researchers are developing new ways to study cilia in human cells and are looking at how TULP3 mutations found in patients might affect its role. By understanding TULP3's precise role, we hope to learn more about the root causes of these diseases.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding genetic mutations related to ciliary diseases.
Not a fit: Patients seeking immediate treatment or clinical interventions would not directly benefit from this early-stage basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the fundamental causes of many diseases linked to cilia dysfunction, potentially opening doors for new treatments.
How similar studies have performed: This project aims to uncover novel functions of TULP3, building on existing knowledge but exploring previously unknown aspects of ciliary biology.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Turn, Rachel Elizabeth — Stanford University
- Study coordinator: Turn, Rachel Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.