Understanding how a protein called SHP2 affects bone marrow and blood cell production
SHP2's Regulation of the Bone Marrow Stroma and Hematopoietic Crosstalk
This research explores how a specific protein called SHP2 influences the health of your bone marrow and the making of blood cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11168685 on NIH RePORTER |
What this research studies
Our bone marrow contains special cells that help create all your blood cells and keep your bones strong. This project looks at a protein called SHP2 and how it guides these special bone marrow cells, called O+SPCs, to become different types of cells, like bone or fat cells. We believe that when SHP2 isn't working correctly in these cells, it can change the bone marrow environment and affect how your body makes blood cells. By understanding this process, we hope to uncover new ways to support healthy blood cell production and potentially address blood disorders.
Who could benefit from this research
Good fit: Patients who are 21 years or older and have conditions related to bone marrow health or blood cell production, such as certain types of leukemia (AML), might find this research relevant.
Not a fit: Patients whose conditions are unrelated to bone marrow function or blood cell formation would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new insights into conditions affecting bone marrow and blood cell production, potentially guiding future treatments for blood disorders like AML.
How similar studies have performed: Preliminary data from this team and findings from other studies on related proteins suggest that influencing these bone marrow cells can impact bone health and blood cell production, supporting this novel hypothesis.
Where this research is happening
Providence, United States
- Rhode Island Hospital — Providence, United States (Active)
Researchers
- Principal investigator: Yang, Wentian — Rhode Island Hospital
- Study coordinator: Yang, Wentian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.