Understanding how a protein called PLCbeta works in diseases like cancer
Mechanisms Underlying Regulation of PLCbeta by heterotrimeric G proteins
This research aims to understand how a key protein called PLCbeta is turned on and off, which is important for cell growth and survival and plays a role in conditions like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11161592 on NIH RePORTER |
What this research studies
Our cells rely on proteins like PLCbeta to respond to signals from outside, which then increases calcium inside the cell to control important processes like cell growth and survival. When PLCbeta doesn't work correctly, it can contribute to serious health issues such as heart disease, cancer, and addiction. This project focuses on figuring out the exact steps of how PLCbeta is activated by other proteins called G proteins. By looking closely at these interactions, we hope to uncover the precise molecular details that have remained unclear, even with advanced imaging techniques.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients but aims to benefit individuals with conditions like cancer, heart disease, or addiction by providing insights for future therapies.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of fundamental cell processes, potentially opening new avenues for developing treatments for diseases where PLCbeta is involved, such as various cancers.
How similar studies have performed: While previous studies have provided some insights, recent advanced imaging has shown that existing models for PLCbeta activation are incomplete, indicating this approach is novel in seeking a more precise understanding.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Lyon, Angeline Marie — Purdue University
- Study coordinator: Lyon, Angeline Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.