Understanding how a protein called Perilipin 5 works in fat cells
Perilipin 5 in the Regulation of Adipose Tissue Function
This work explores how a protein in fat cells, Perilipin 5, might help manage obesity and type 2 diabetes by encouraging the body to burn more energy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11126024 on NIH RePORTER |
What this research studies
Obesity and type 2 diabetes are growing health concerns that increase the risk for many other serious conditions. Researchers are looking for new ways to help the body burn excess energy, and one promising area involves special fat cells called brown and beige adipocytes, which can generate heat. This project aims to understand how a specific protein, Perilipin 5, influences these fat cells. By learning more about Perilipin 5, we hope to find new strategies to activate these energy-burning fat cells.
Who could benefit from this research
Good fit: This foundational research is relevant to adults aged 21 and older who are affected by or at risk for adult-onset diabetes mellitus and obesity.
Not a fit: Patients not affected by obesity or type 2 diabetes may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity, type 2 diabetes, and related conditions by helping the body burn more calories.
How similar studies have performed: This work builds upon a long-standing research program and a growing body of literature that has implicated Perilipin 5 in fat cell function.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Bickel, Perry E — Ut Southwestern Medical Center
- Study coordinator: Bickel, Perry E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.