Understanding how a protein called PDK4 affects energy use in cells
Novel roles of PDK4 in regulating mitochondrial protein phosphorylation, carbon flux and metabolic resilience
This study is looking at a protein called PDK4 to see how it affects how our cells use energy and nutrients, which could help improve metabolic health for people dealing with energy-related issues like those from fasting or exercise.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11034095 on NIH RePORTER |
What this research studies
This research investigates the role of PDK4, a protein that helps regulate how cells use energy and process nutrients. By studying how PDK4 influences mitochondrial function and carbon trafficking, researchers aim to uncover its potential as a therapeutic target for improving metabolic health. The approach includes advanced techniques like mass spectrometry to analyze protein interactions and modifications in heart and muscle tissues. This could lead to new insights into how our bodies respond to energy stresses such as fasting or exercise.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders or conditions that affect energy metabolism.
Not a fit: Patients with stable metabolic health or those not experiencing energy regulation issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic disorders and improve energy regulation in patients.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways similar to those involving PDK4, indicating potential for success.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Muoio, Deborah M — Duke University
- Study coordinator: Muoio, Deborah M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.