Understanding how a protein called nephronectin helps neurons connect correctly in the brain
Investigating the Role of Nephronectin in Establishing Retinotectal Circuit Specificity
This study is looking at a special protein called nephronectin to see how it helps brain cells connect with each other correctly, which could help us understand how the brain keeps its connections organized.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10910112 on NIH RePORTER |
What this research studies
This research investigates the role of nephronectin, a protein found in the extracellular matrix, in guiding neurons to form precise connections in the brain. By examining how this protein interacts with specific neurons in the superior colliculus, the study aims to uncover the mechanisms that ensure neurons connect with the right partners. The approach involves screening for proteins that are differentially expressed in certain neurons and analyzing their effects on synaptic specificity. This could provide insights into how the nervous system maintains its complex wiring.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions affecting neuronal connections or those at risk for degenerative neurological disorders.
Not a fit: Patients with established neurological conditions unrelated to synaptic specificity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurological disorders by enhancing our understanding of neuronal connectivity.
How similar studies have performed: Other research has shown promising results in understanding neuronal connectivity through similar molecular approaches, indicating that this line of inquiry is both relevant and potentially impactful.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Tsai, Nicole Y — University of California, San Francisco
- Study coordinator: Tsai, Nicole Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.