Understanding how a protein called Muscle LIM affects heart function in hypertrophic cardiomyopathy
Modulation of heart function by Muscle LIM protein-mediated mechanotransduction
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11118857
This work explores how a specific protein helps the heart sense force, aiming to find new ways to help people with an inherited heart condition called hypertrophic cardiomyopathy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11118857 on ClinicalTrials.gov |
What this research studies
Familial hypertrophic cardiomyopathy (HCM) is a common inherited heart disease where the heart muscle thickens, leading to serious problems like heart failure and sudden cardiac death. We don't fully understand how abnormal muscle forces in HCM lead to this damage, which makes it hard to develop new treatments. This project uses heart cells grown from patient-specific stem cells to create tiny engineered heart tissues. By studying these tissues and using computer models, we are uncovering a new way the heart senses and responds to force, which could lead to better therapies for HCM.
Who could benefit from this research
Good fit: This foundational work is most relevant to patients with familial hypertrophic cardiomyopathy, especially those with sarcomeric gene mutations.
Not a fit: Patients without hypertrophic cardiomyopathy or related genetic heart conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new and more effective treatments for familial hypertrophic cardiomyopathy by targeting newly discovered pathways.
How similar studies have performed: This project builds on existing insights from patients with severe HCM and has already identified a new pathway, suggesting a promising direction for further investigation.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QYANG, YIBING — YALE UNIVERSITY
- Study coordinator: QYANG, YIBING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.