Understanding how a protein called Kindlin-2 works in cell membranes, which is important for conditions like cancer
Atomic Resolution Characterization of Kindlin-2 Binding to Phosphatidylinositol Phosphatases in Lipid Bilayers by Solid-State NMR
['FUNDING_R01'] · RUTGERS, THE STATE UNIV OF N.J. · NIH-11114018
This project aims to understand the detailed structure and function of a protein called Kindlin-2 and how it interacts with cell membranes, which could help us learn more about diseases like cancer and diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS, THE STATE UNIV OF N.J. (nih funded) |
| Locations | 1 site (PISCATAWAY, UNITED STATES) |
| Trial ID | NIH-11114018 on ClinicalTrials.gov |
What this research studies
Kindlin-2 is a protein found on the surface of our cells that helps control how cells stick together, a process called cell adhesion. This cell adhesion is crucial for many body functions, but when it goes wrong, it can contribute to diseases like cancer. This project uses a special technique called Solid-State NMR to get a very close look at Kindlin-2 and the fatty layers (lipid membranes) it attaches to. By understanding these tiny interactions at an atomic level, we hope to uncover how Kindlin-2's activity is regulated. This deeper knowledge could provide new insights into how cell adhesion works and how its disruption contributes to various health problems.
Who could benefit from this research
Good fit: This foundational laboratory research does not involve direct patient participation, but its findings could eventually benefit patients with conditions related to cell adhesion, such as certain cancers or diabetes.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions would not find direct benefit from participating in this basic science project.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into cell adhesion and signaling pathways, potentially leading to new strategies for treating diseases like cancer and diabetes in the future.
How similar studies have performed: Solid-state NMR is a well-established technique for studying molecular structures, and similar fundamental research has successfully advanced our understanding of biological processes.
Where this research is happening
PISCATAWAY, UNITED STATES
- RUTGERS, THE STATE UNIV OF N.J. — PISCATAWAY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIEUWKOOP, ANDREW — RUTGERS, THE STATE UNIV OF N.J.
- Study coordinator: NIEUWKOOP, ANDREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers