Understanding how a protein called IRP2 controls iron in blood cells
Cell Cycle Regulation of IRP2 Phosphorylation During Hematopoiesis
['FUNDING_R01'] · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · NIH-11141919
This project explores how a specific protein helps manage iron in blood cells, which could lead to new ways to help people with blood disorders like anemia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11141919 on ClinicalTrials.gov |
What this research studies
Iron is vital for our cells to grow, make DNA, and produce hemoglobin, which carries oxygen in our blood. This project looks at a key protein called IRP2 that helps control how our bodies use iron. Researchers are focusing on how a specific change to IRP2, called phosphorylation, affects its ability to manage iron during the cell's growth cycle. They are also studying how problems with this process can lead to conditions like anemia, where the body doesn't have enough healthy red blood cells. The goal is to understand how disruptions in this iron regulation contribute to blood cell development issues and anemia.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the basic mechanisms behind blood diseases, particularly those involving iron regulation and anemia.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not directly benefit from this early-stage basic science.
Why it matters
Potential benefit: If successful, this work could uncover new targets for treatments that correct iron imbalances and improve conditions like anemia.
How similar studies have performed: While the general mechanisms of iron regulation are known, this specific focus on cell-cycle dependent phosphorylation of IRP2 and its link to anemia is a novel area of investigation.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEIBOLD, ELIZABETH ANN — UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- Study coordinator: LEIBOLD, ELIZABETH ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Diseases