Understanding how a protein called HuR affects lung disease in people with HIV
The Role of HuR in HIV related COPD
This research explores how cigarette smoke and HIV infection together lead to lung disease, focusing on a protein called HuR that helps protect the lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Suny Downstate Medical Center NIH-funded |
| Lab location | 1 site (Brooklyn, United States) |
| Project ID | NIH-11115863 on NIH RePORTER |
What this research studies
We know that HIV infection and cigarette smoking can make lung disease, like COPD, worse for many people. This project looks closely at how a specific protein, called HuR, acts as a protector in lung cells. When HuR levels drop due to HIV and smoke, lung cells become more vulnerable to damage and inflammation. Researchers are also exploring another protein, c-Src, which seems to reduce HuR, to better understand this complex process. By understanding these connections, we hope to find new ways to protect the lungs of people living with HIV.
Who could benefit from this research
Good fit: This research is focused on understanding lung disease in people living with HIV who are also exposed to cigarette smoke.
Not a fit: Patients who do not have HIV or who do not smoke may not directly benefit from the specific findings of this particular research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or ways to prevent severe lung disease in people living with HIV who smoke.
How similar studies have performed: Previous work has identified connections between HIV, smoking, and lung damage, and this project builds on those findings to explore a specific protective protein.
Where this research is happening
Brooklyn, United States
- Suny Downstate Medical Center — Brooklyn, United States (Active)
Researchers
- Principal investigator: Foronjy, Robert F — Suny Downstate Medical Center
- Study coordinator: Foronjy, Robert F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.