Understanding How a Protein Called GATA4 Keeps Stomach Cells Healthy
Defining GATA4's Molecular Function in Gastric Cell Biology
This research explores how a protein called GATA4 helps stomach cells work properly, which is important for digestion and preventing diseases like ulcers and stomach cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-11159779 on NIH RePORTER |
What this research studies
Our stomach cells, called parietal cells, are vital for digestion and protecting us from infections by producing acid and growth factors. When these cells don't work right, it can lead to serious conditions like chronic gastritis, ulcers, and even stomach cancer. We've found that a specific protein, GATA4, seems to be a major controller of how these important cells develop and function. This project aims to uncover exactly how GATA4 works to keep your stomach healthy and prevent these common digestive problems.
Who could benefit from this research
Good fit: This foundational work is relevant to anyone affected by stomach conditions such as chronic gastritis, peptic ulcers, or stomach cancer.
Not a fit: Patients not affected by stomach cell dysfunction or related diseases would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat stomach diseases by targeting GATA4.
How similar studies have performed: While the importance of stomach cells is well-known, this specific focus on GATA4's role in their health represents a novel area of exploration.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Battle, Michele a — North Carolina State University Raleigh
- Study coordinator: Battle, Michele a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.